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Clinical Characteristics and Genotype of Rotavirus Infection in Newborn Infants / 대한주산의학회잡지
Article in Korean | WPRIM (Western Pacific) | ID: wpr-59322
Responsible library: WPRO
ABSTRACT

PURPOSE:

This study was conducted to investigate the incidence of rotavirus infection and common rotavirus strains of newborn infants admitted to the NICU and elucidate association, between rotavirus infection and clinical symptoms, and the significance of rotavirus antigen test.

METHODS:

From July 2010 to June 2011, stools of 408 newborns admitted into the NICU were tested for rotavirus antigen by enzyme-linked fluorescent assay. Rotavirus positive stools were performed RT-PCR.

RESULTS:

A total of 408 stool samples were examined by VIDAS Rotavirus(R), and 128 specimens (31.4%) were proven positive. One hundred thirteen fecal specimens were eligible for RT-PCR and rotavirus was detected in 42 samples (10.3%). PCR (+) prevalence of antigen positive infants was significantly lower in 1-2 postnatal days group than infants older than three days after birth (P<0.001). Out of the 42 PCR positive infants, there were 26 (62%) symptomatic infants. Seventeen infants had fever, 15 had diarrhea, and 3 experienced vomiting. Rest of the 16 patients (38%) did not show any symptoms. The most common strain was G4P[6] (n=40, 95.2%), followed by G4P[8] (n=1, 2.4%), and G3P[3] (n=1, 2.4%).

CONCLUSIONS:

Rotavirus infection rate in the NICU was 31.4% in the antigen test and 11.7% in the PCR test. False positive rate of rotavirus antigen test was significantly higher in 1-2 postnatal days group. Thus, it should be considered to apply different RFV standards from adults when rotavirus antigen test result is evaluated in newborn infants. The most common strain of rotavirus was G4P[6].
Subject(s)

Full text: Available Health context: Neglected Diseases Health problem: Diarrhea / Neglected Diseases Database: WPRIM (Western Pacific) Main subject: Rotavirus Infections / Sprains and Strains / Vomiting / Polymerase Chain Reaction / Incidence / Prevalence / Rotavirus / Parturition / Diarrhea / Fever Type of study: Practice guideline / Incidence study / Prevalence study / Prognostic study Limits: Adult / Humans / Infant / Infant, Newborn Language: Korean Journal: Korean Journal of Perinatology Year: 2012 Document type: Article
Full text: Available Health context: Neglected Diseases Health problem: Diarrhea / Neglected Diseases Database: WPRIM (Western Pacific) Main subject: Rotavirus Infections / Sprains and Strains / Vomiting / Polymerase Chain Reaction / Incidence / Prevalence / Rotavirus / Parturition / Diarrhea / Fever Type of study: Practice guideline / Incidence study / Prevalence study / Prognostic study Limits: Adult / Humans / Infant / Infant, Newborn Language: Korean Journal: Korean Journal of Perinatology Year: 2012 Document type: Article
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