Drug Resistance of Lower Respiratory Tract Infection with Gram-negative Bacilli in Grass-roots Hospitals / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate drug resistance of hospital acquired lower respiratory tract infection with Gram-negative bacilli in grass-roots hospitals and to provide the scientific reference for clinically reasonable use of antibiotics. METHODS Referring to Nationwide Rules of Operation in Clinical Laboratory,the strains were isolated and identified. The antibiotic susceptibility test was performed by K-B method. RESULTS Among 199 strains of Gram-negative bacilli,the top 4 of isolating rate were Pseudomonas aeruginosa (PAE),Klebsiella pneumoniae (KPN),Acinetobacter baumannii (ACB) and Escherichia coli (ECO). The drug-resistance supervision in vitro manifested ascending tendency of drug resistance in four kinds of important pathogenic bacteria. The susceptibility of Enterobacteriaceae to imipenem and meropenem was 100%,while the resistance rate of PAE and ACB arrived at 8.0-10.0%. The detection rate of extensive-spectrum beta-lactamases (ESBLs) producing ECO and KPN was 29.2% and 30.6%,respectively. CONCLUSIONS The drug resistance of lower respiratory tract infection with Gram-negative bacilli in grass-roots hospitals show ascending tendency. We should strengthen the management of hospital infection.