Mechanisms underlying the antibiotic resistance of Pseudomonas aeruginosa / 医学研究生学报

ABSTRACT

Pseudomonas aeruginosa,a ubiquitous organism,shows a remarkable resistance to antibiotics because of its low permeability of the outer-membrane,over-expression of efflux pumps,inactivation of antibotics,or mutations in targets.These mechanisms are often present simultaneously,and increase the burden on clinical therapy.