Relationship between Atopic Status and Immunoregulatory Cytokines in Respiratory Syncytial Virus Bronchiolitis / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
; : 30-37, 2004.
Article
in Ko
| WPRIM
| ID: wpr-59704
Responsible library:
WPRO
ABSTRACT
PURPOSE: Recent studies have demonstrated and suggested that Interleukin (IL) -10 and IL-11 are implicated in the pathophysiology of RSV infection and may act in the regulation of inflammatory response. We measured IL-10 and IL-11 in nasal secretions of infants with acute RSV bronchiolitis to investigate if there is any difference in the production of these anti-inflammatory cytokines between atopic and non-atopic subjects. METHODS: We measured IL-10, IL-11 in nasal secretions of 44 infants (20 were atopic) with acute RSV bronchiolitis. The nasal secretion samples were obtained from patients on admission and stored immediately at -70degrees C until analysis. Atopy was defined as having at least one positive skin prick test to common allergens, a positive history of atopic dermatitis or age-matched, high serum IgE level. RESULTS: IL-10 and IL-11 increased significantly in nasal secretion of infants with acute RSV bronchiolitis. Both IL-10 and IL-11 were significantly lower in atopic patients than in non-atopic patients. There was no significant relation between the severity of symptoms and IL-10 or IL-11 levels. CONCLUSION: Our study showed that both IL-10 and IL-11 increased in nasal secretion during acute RSV bronchiolitis, and the levels were significantly lower in atopic patients than in non-atopic patients. It suggests that the airway inflammation induced by RSV may be different between atopic and non-atopic patients and this may be associated with lower induction of these anti-inflammatory cytokines in atopic patients.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Respiratory Syncytial Viruses
/
Skin
/
Immunoglobulin E
/
Bronchiolitis
/
Allergens
/
Cytokines
/
Interleukins
/
Interleukin-10
/
Interleukin-11
/
Dermatitis, Atopic
Limits:
Humans
/
Infant
Language:
Ko
Journal:
Pediatric Allergy and Respiratory Disease
Year:
2004
Document type:
Article