Expression levels of IL-37 and HBeAg seroconversion in chronic HBV patients / 中国免疫学杂志
Chinese Journal of Immunology
; (12): 1545-1548,1552, 2015.
Article
in Zh
| WPRIM
| ID: wpr-602598
Responsible library:
WPRO
ABSTRACT
Objective:Detecting serum IL-37 concentrations and HBeAg seroconversion in chronic hepatitis B virus(HBV) patients during the treatment of telbivudine( LDT).Methods:Fifty patients with chronic hepatitis B were included in the study;and 20 healthy people were selected as the control group.The expression levels of interleukin ( IL)-37, IL-6 and CRP were measured by enzyme-linked immunosorbent assay.As the same time,the relationship between serum IL-37 concentrations and HBeAg seroconversion was dynamically observed at 0 w,12 w,24 w,36 w,48 w after treatment.Results:The serum levels of IL-37 in chronic HBV patients were higher than the control group at baseline(q=22.716,P0.05).Conclusion:IL-37 may be involved in the process of HBV infection in CHB patients,and can reflect the degree of liver’ s inflammatory damage.IL-37 may play a significant role in the immune response of CHB patients with HBeAg seroconversion.In future,IL-37 may be an effective therapeutic measure to HBV infection.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Immunology
Year:
2015
Document type:
Article