Simvastatin enhances the radiosensitivity of esophageal squamous cell carcinoma / 西安交通大学学报(医学版)
Journal of Xi'an Jiaotong University(Medical Sciences)
; (6): 565-568,581, 2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-604286
Responsible library:
WPRO
ABSTRACT
Objective To study the effect of simvastatin on the radiosensitivity of esophageal squamous cell carcinoma .Methods Interrupted radiation was used to induce the radioresistance EC 9706 ,named R‐resistant cell . The effect of simvastatin on the proliferation and radiosensitivity of EC 9706 and R‐resistant cells were examined by Cell Counting Kit‐8 assay and colony formation assay ,respectively .Results The radioresistance EC9706 ,named R‐resistant ,was induced successfully .The results of Counting Kit‐8 assay and colony formation assay indicated that simvastatin could sensitize EC9706 and the radioresistance of R‐resistant to irradiation .Conclusion Simvastatin can sensitize esophageal squamous cell carcinoma to irradiation .
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Xi'an Jiaotong University(Medical Sciences)
Year:
2016
Document type:
Article