Type Ⅲ TGF-βreceptor mediated signaling pathway and its role in fibrotic diseases / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 1629-1633,1634, 2016.
Article
in Zh
| WPRIM
| ID: wpr-605965
Responsible library:
WPRO
ABSTRACT
Transforming growth factor β(TGF-β)superfamily ligands play an important role in regulating cellular homeostasis including proliferation,differentiation,apoptosis,immune sur-veillance and angiogenesis.Type Ⅲ TGF-βreceptor (TβRⅢ) is considered to be the coreceptor of TGF-βsuperfamily.TβRⅢnot only has an effect on classical Smad signaling pathway,but also on non-Smad signaling pathway.TβRⅢplays a crucial role in fibrosis,tumor,cardiovascular diseases via mediating kinds of signaling pathways.This paper reviews TβRⅢ mediated sig-naling pathway and its role in fibrotic diseases.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2016
Document type:
Article