Prevention Effects of Different Treatment Courses of Antibiotics in Fracture Patients during Perioperative Period of Incision Internal Fixtion: A Meta-Analysis / 中国药房
China Pharmacy
; (12): 3390-3394, 2017.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-607087
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To systematically evaluate therapeutic efficacies of perioperative application of single-dose and multipie-dose of antibiotics for preventing surgical site infection after closed fractures patients receive incision and internal fixation,and to provide evidence-based reference.METHODS:
Retrieved from PubMed,EMBase,CBM,Cochrane Library,CBM,CJFD,VIP and Wanfang database,RCTs about perioperative application of single-dose (trial group) and multiple-dose (control group) of antibiotics for preventing surgical site infection after closed fractures patients receive incision and internal fixation were collected.Meta-analysis was performed using Rev Man 5.3 statistical software after literature screening,data extraction and quality evaluation by improved Jadad.RESULTS:
Finally 8 clinical studies were included,involving 3 457 patients.The results of Meta-analysis showed that there was no statistical significance in the rate of surgical site infection [OR=1.02,95% CI(0.63,1.66),P=0.94)].Cefazolin stadies were included in subgroup analysis according to drug use,and results of Meta-analysis showed that there was no statistical significance in the rate of surgical site infection[OR=1.33,95%CI(0.55,3.20),P=0.52].CONCLUSIONS:
Prophylactic application of single-dose of antibiotics is recommended for preventing surgical site infection after closed fractures patients receive incision and internal fixation.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Systematic review
Language:
Chinese
Journal:
China Pharmacy
Year:
2017
Document type:
Article