Controversies of Sepsis-3 / 中国小儿急救医学

ABSTRACT

Sepsis caused by infection is one of the most common diseases in ICU.In 1991,the concept of sepsis was first put forward for the purpose of unifying cognition,early diagnosis and treatment,and reducing the fatality rate of severe infection.Over the past 20 years,with the development of the septic pathophysiology,its definition and clinical criteria have been constantly updated and improved.In 2016,a task force convened by European Society of Intensive Care Medicine and the Society of Critical Care Medicine revised the definition and clinical criteria of sepsis,namely,Sepsis-3.It mainly emphasizes infection leading to homeostasis disequilibrium,and organ dysfunction with potentially fatal risk.The definition is updated each time;many new theories or ideas are incorporated,and are also some controversies.This review focused on the definition and clinical criteria of sepsis,and the controversies of Sepsis-3.