Distribution and Resistance of Bacterial Isolated from Blood of Malignant Tumour Patients / 医药导报

ABSTRACT

Objective To investigate the distribution and susceptibility of isolated organisms from blood of malignant tumour patients.Methods Isolates from blood culture in patients with cancer during January 2013 to December 2015 were analyzed.Results were analyzed according to the breakpoints of CLSI 2014.Results Total of 498 isolates from blood culture,gram-negative bacilli accounted for 58.0% and gram-positive cocci accounted for 42.0%.The most common pathogens were E.coli,Coagulase-negative Staphylococcus,Klebsiella spp, S.aureus and Enterococcus spp.Drug resistance of E.coli strains to piperacillin-tazobactam,amikacin and imipenem were low,and drug resistance of E.coli strains to ampicillin-sulbactam,gentamicin,ciprofloxacin,levofloxacin and compound sulfamethoxazole were high.The prevalence of ESBL-producing strains was 70.7% in E.coli and 22.8% in Klebsiella spp.The E.coli and Klebsiella spp.strains isolated from ICU showed higher resistance than the strains from surgery and medicine department.The E.faecium strains were highly susceptible to gentamicin (high level) and lower susceptible to most of the antibiotics tested.The E.faecalis strains were more susceptible than E.faecium to these agents.No vancomycin-resistant strains were found in Enterococcus spp.Conclusion Among gram-negative pathogen isolates from blood culture in cancer patients,E.coli and Klebsiella spp.are the most frequent.Staphylococcus and Enterococcus are the most frequently isolated species of gram-positive cocci.The percentage of Acinetobacter spp.strains is relatively higher in ICU.Surveillance of antimicrobial resistance can provide the basis for rational use of antibiotics.