Regional Brain Perfusion before and after Treatment with Methylphenidate According to the MspI Polymorphism of the Alpha-2A Adrenergic Receptor Gene in Children with Attention-Deficit Hyperactivity Disorder
Journal of the Korean Academy of Child and Adolescent Psychiatry
; : 21-27, 2013.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-61535
Responsible library:
WPRO
ABSTRACT
OBJECTIVES:
Dysregulation of the central noradrenergic system may be involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). The aim of this study was to examine the differences in pre- and post-treatment cerebral perfusion according to the MspI polymorphisms of the alpha-2A-adrenergic receptor gene (ADRA2A) in children with ADHD.METHODS:
Thirty seven drug-naive ADHD children (8.9+1.8 years old, M=32, F=5) were genotyped. Baseline single-photon emission computed tomography (SPECT) and clinical assessments were performed for ADHD children. After treatment with methylphenidate for eight weeks, SPECT and clinical assessment were repeated.RESULTS:
No differences in baseline clinical assessments or cerebral perfusion were observed according to the MspI genotype. However, after treatment, ADHD children with the G/G genotype at the MspI polymorphism showed hyperperfusion in the right cerebellar declive (p=.001, uncorrected) and hypoperfusion in the left lentiform nucleus and left cingulate gyrus (p<.001 and p=.001, uncorrected), compared to children without the G/G genotype.CONCLUSION:
Although the results of this study should be interpreted cautiously, they suggest a possible role of the MspI polymorphisms of the ADRA2A gene in methylphenidate-induced changes in cerebral perfusion.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Perfusion
/
Pharmacogenetics
/
Brain
/
Tomography, Emission-Computed
/
Tomography, Emission-Computed, Single-Photon
/
Receptors, Adrenergic, alpha-2
/
Corpus Striatum
/
Genotype
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Gyrus Cinguli
/
Methylphenidate
Limits:
Child
/
Humans
Language:
Korean
Journal:
Journal of the Korean Academy of Child and Adolescent Psychiatry
Year:
2013
Document type:
Article