Influence of tirofiban on endothelial cell function in patients with myocardial infarction undergoing emergency PCI / 心血管康复医学杂志

ABSTRACT

Objective: To study influence of tirofiban on endothelial cell function in patients with myocardial infarction undergoing emergency percutaneous coronary intervention (PCI).Methods: A total of 124 patients with myocardial infarction, who received emergency PCI in our hospital from Jan 2014 to Jan 2016, were selected.According to random number table, patients were randomly and equally divided into routine treatment group (received unfractionated heparin during PCI) and tirofiban group (received tirofiban hydrochloride before PCI).Concentrations of nitric oxide (NO) and von Willebrand factor (vWF) before, and after PCI 2h, 6h and 36h;and incidence of major adverse cardiovascular events (MACE) during hospitalization were measured and compared between two groups.Results: Compared with before PCI, on 2h, 6h and 36h after PCI, there was significant reduction in NO concentration, and significant rise in vWF concentration in routine treatment group (P0.05 all), significant rise in vWF concentrations on 2h and 6h (P<0.01 both), but that of 36h had no significant difference compared with before PCI in tirofiban group, P=0.879.Compared with routine treatment group, on 2h, 6h and 36h after PCI, there were significant rise in NO concentration [6h (40.46±9.79) μmol/L vs.(54.84±10.76)μmol/L, 36h (49.42±9.82) μmol/L vs.(55.39±12.34)μmol/L], and significant reduction in vWF concentration [6h (243.14±19.99) μmol/L vs.(121.58±18.92) μmol/L, 36h (223.38±19.76) μmol/L vs.(105.32±23.05) μmol/L] in tirofiban group, P<0.05 or <0.01.Incidence rate of MACE during hospitalization in tirofiban group was significantly lower than that of routine treatment group (4.8% vs.16.1%), P=0.040.Conclusion: Application of tirofiban in patients with myocardial infarction during emergency PCI can significantly improve endothelial cell function and reperfusion effect, which is worth extending.