The effect of the small dose dopamine on the surgical rate, curative effect and adverse effects of neonatal necrotizing enterocolitis / 中国生化药物杂志

ABSTRACT

Objective To investigate the effect of the small dose dopamine on the surgical rate, curative effect and adverse reactions of the neonatal necrotic enteritis. Methods From January 2013 to January 2017 in our hospital for treatment of 60 cases of neonatal necrotizing enterocolitis were as the research object, and to give a randomized, control group 30 cases, give simple phentolamine static drop treatment; Intervention group, 30 cases in the control group on the basis of small dose dopamine was given to two groups of children with fasting time, length of hospital stay, operation rate, efficacy and adverse reactions happen to comprehensive evaluation. Results The average fasting time and hospital length of the intervention group were significantly better than the control group (P< 0.05), which was statistically significant. Intervention group with operation rate and total effective rate were 3.3％, 93.3％, the control rate of surgery, treatment in children with total effective rate of 16.7％, 70.0％ respectively, there are statistically significant difference (P< 0.05); There were only two cases of adverse reaction in the intervention group, 6.7％, and the difference of 23.3％ in the control group was statistically significant (P< 0.05). Conclusion On the basis of phentolamine treatment of neonatal necrotizing enterocolitis with small dose of dopamine was given to shortening the time of fasting and hospitalization time, decrease the rate of transit operation, and less adverse reaction, curative effect is distinct, worthy of clinical popularization and application.