Advances in childhood T-cell acute lymphoblastic leukemia and inhibitors targeting PI3K-Akt-mTOR signaling pathway / 白血病·淋巴瘤

ABSTRACT

T-cell acute lymphoblastic leukemia (T-ALL) is a hematopoietic malignancy derived from T precursor cells. Morbidity of children accounted for 15%of ALL. Studies have found that PI3K-Akt-mTOR signaling pathway is associated with the occurrence of T-ALL, cell proliferation, cell apoptosis and drug resistance. The PI3K-Akt-mTOR signaling pathway inhibitors, which can target to inhibit T-ALL cell proliferation in the treatment of T-ALL children, plays an effective cytotoxic role. By shortening the duration of treatment, it can significantly improve the quality of life of children with T-ALL and reducing disease recurrence. It is a more effective way for traditional chemotherapy resistant T-ALL children patients.