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Effect of pidotimod on immunologic functions and clinical curative efficacy for patients undergoing recurrent respiratory tract infections / 药物评价研究
Drug Evaluation Research ; (6): 679-682, 2017.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-619631
Responsible library: WPRO
ABSTRACT
Objective To evaluate the effect of pidotimod combined with antibacterials on the immunologic functions and clinical curative efficacy for patients undergoing recurrent respiratory tract infections.Methods Patients with recurrent respiratory tract infections (150 cases) were enrolled in Matemal and Child Health Hospital of Guangyuan from August 2013 to January 2016,which divided to two groups randomly,Group A (n =75) accepted traditional antibacterials treatment,and Group B (n =75) adopted pidotimod combined with antibacterials.The clinical symptom and immunologic functions of patients during treatment were tested,and the clinical curative efficacy of patients was evaluated in the follow-up period.Results After treatment,the disappear time of cough,fever,tonsil inflammation and pulmonary wheezing in treatment group was significantly shorter than that of control group (P < 0.05).After treatment,the levels of serum immunoglobulin in two groups were higher than those before treatment (P < 0.05),and the treatment group was significantly higher than control group (P < 0.05).After treatment,the relative activities of CD3+,CD4+,CD8+,and NK cells in two groups increased significantly (P < 0.05),the relative content of CD4+/CD8+ was also increased (P <0.05),and the improvement of above indexes in the treatment group was more obvious than those in control group (P < 0.05).After treatment,total effective rate of treatment group was significantly higher than that of control group (P < 0.05),the recurrence of infection in the treatment group is significantly lower than that in the control group (P < 0.05),and the recurrence duration was significantly shorter than control group (P < 0.05).Conclusion The clinical curative of pidotimod combined with antibacterials was remarkable for patients of recurrent respiratory tract infections,which deserved popularization not only improving the immunologic functions,but also decreasing the times of recurrence.

Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Drug Evaluation Research Year: 2017 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Drug Evaluation Research Year: 2017 Document type: Article
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