The Effect of Propofol on Pruritus induced by Epidural Morphine / 대한마취과학회지
Korean Journal of Anesthesiology
; : 423-426, 1997.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-62022
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Epidural morphine is used commonly for postoperative pain control. But, pruritus, although trivial, is a common side effect. It is reported that subhypnotic doses of propofol are effective against pruritus induced by epidural or subarachnoid morphine.METHODS:
Sixty five patients received epidural morphine 4 mg bolus and 4 mg/day with continuous infusion for 2 days via Baxter infusor. The patients who have pruritus with scratching were allocated randomly to receive either 1 ml propofol(10 mg) or 1 ml placebo(Intralipos ) intravenously. Pruritus was assessed 5 min later using a pruritus rating scale with double-blind, placebo-controlled study.RESULTS:
Forty patients showed pruritus with scratching. The overall success rate in treating pruritus was 75% in propofol group and 25% in placebo group. Compared with placebo, propofol was effective significantly(P<.05).CONCLUSIONS:
These results suggest that propofol in a subhypnotic dose is an efficient drug treatment for epidural morphine induced pruritus.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pain, Postoperative
/
Pruritus
/
Infusion Pumps
/
Propofol
/
Analgesics
/
Anesthetics
/
Morphine
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1997
Document type:
Article