HLA-B*1502 and carbamazepine induced StevensJohnson syndrome/toxic epidermal necrolysis in Indonesia
Neurology Asia
; : 113-116, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-625487
Responsible library:
WPRO
ABSTRACT
Background & Objective:
Association between HLA-B*1502 and carbamazepine-induced StevenJohnson syndrome/toxic epidermal necrolysis (CBZ-SJS/TEN) was reported in many Southeast Asian populations but not in Indonesian. The purpose of this study was to evaluate the association between HLA-B*1502 andCBZ-SJS/TEN in an Indonesian population.Methods:
Patients with history of CBZ-SJS/TEN are recruited as cases and those who tolerated CBZ as controls. HLA-B typing was performed.Results:
We recruited 14 cases with CBZ-SJS/TEN and 53 controls. Positive HLA-B*1502 was found in 8 (57.1%) cases and 14 (26.4%) controls (OR 3.7, 95% CI 1.09-12.61, p=0.035).Conclusion:
HLA-B*1502 is associated with CBZ-SJS/TEN patients in Indonesian.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
English
Journal:
Neurology Asia
Year:
2017
Document type:
Article