Hypertriglyceridemia and Cardiovascular Diseases: Revisited
Korean Circulation Journal
; : 135-144, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-62942
Responsible library:
WPRO
ABSTRACT
Residual cardiovascular risk and failure of high density lipoprotein cholesterol raising treatment have refocused interest on targeting hypertriglyceridemia. Hypertriglyceridemia, triglyceride-rich lipoproteins, and remnant cholesterol have demonstrated to be important risk factors for cardiovascular disease; this has been demonstrated in experimental, genetic, and epidemiological studies. Fibrates can reduce cardiovascular event rates with or without statins. High dose omega-3 fatty acids continue to be evaluated and new specialized targeting treatment modulating triglyceride pathways, such as inhibition of apolipoprotein C-III and angiopoietin-like proteins, are being tested with regard to their effects on lipid profiles and cardiovascular outcomes. In this review, we will discuss the role of hypertriglyceridemia, triglyceride-rich lipoproteins and remnant cholesterol on cardiovascular disease, and the potential implications for treatment stargeting hypertriglyceridemia.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Triglycerides
/
Cardiovascular Diseases
/
Hypertriglyceridemia
/
Epidemiologic Studies
/
Fatty Acids, Omega-3
/
Cholesterol
/
Risk Factors
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Apolipoprotein C-III
/
Fibric Acids
Type of study:
Etiology study
/
Observational study
/
Risk factors
Language:
English
Journal:
Korean Circulation Journal
Year:
2016
Document type:
Article