The fundamentals of tissue engineering: new scaffolds
The Medical Journal of Malaysia
; : 89-90, 2004.
Article
in Ml
| WPRIM (Western Pacific)
| ID: wpr-629937
Responsible library:
WPRO
ABSTRACT
The ability to regenerate new bone for skeletal use is a major clinical need. In this study, two novel porous calcium phosphate materials pure HA and biphasic HA/beta-Tricalcium phosphate (HA/beta -TCP) were evaluated as potential scaffolds for cell-seeded bone substitutes using human osteoblast-like cells (HOS) and primary human mesenchymal stem cells (hMSCs). A high rate of proliferation was observed on both scaffolds. A greater increase in alkaline phosphatase (ALP- an indicator of osteoblast differentiation) was observed on HA/beta -TCP compared to HA. This observation indicates that HA/TCP may play a role in inducing osteoblastic differentiation. Although further evaluation is required both materials show potential as innovative synthetic substitutes for tissue engineered scaffolds.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Organ Culture Techniques
/
Safety
/
Keratinocytes
/
Immunotherapy, Adoptive
/
Chondrocytes
/
Tissue Engineering
/
Equipment and Supplies
/
Japan
Country/Region as subject:
Asia
Language:
Ml
Journal:
The Medical Journal of Malaysia
Year:
2004
Document type:
Article