Plasma neutrophil gelatinase-associated lipocalin as a potential predictor of adverse renal outcomes in immunoglobulin A nephropathy
The Korean Journal of Internal Medicine
; : 345-353, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-63000
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Neutrophil gelatinase-associated lipocalin (NGAL) is a well-known biomarker of acute kidney injury. We evaluated the value of plasma NGAL (pNGAL) as an independent predictor of prognosis in immunoglobulin A nephropathy (IgAN).METHODS:
In total, 91 patients with biopsy-proven IgAN at a single center were evaluated. pNGAL was measured using a commercial enzyme-linked immunosorbent assay kit (R&D Systems). Adverse renal outcome was defined as chronic kidney disease (CKD) stage 3 or above at the last follow-up. Pearson correlation coefficient and Cox regression were used for analyses.RESULTS:
The mean age of all patients (malefemale, 4843) was 35 years (range, 18 to 77). pNGAL ranged between 21.68 and 446.40 ng/mL (median, 123.97) and showed a correlation with age (r = 0.332, p = 0.001), creatinine (r = 0.336, p = 0.001), estimated glomerular filtration rate (r = -0.397, p 1 g/day (HR, 5.184; 95% CI, 1.124 to 23.921; p = 0.035), and pNGAL (HR, 1.012; 95% CI, 1.003 to 1.022; p = 0.013) were independent predictors associated with adverse renal outcome.CONCLUSIONS:
pNGAL showed strong correlations with other clinical prognostic factors and was also an independent predictor of adverse renal outcome. We suggest pNGAL as a potential predictor for prognosis in IgAN, while further studies are needed to confirm the clinical value.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Time Factors
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Biopsy
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Acute-Phase Proteins
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Enzyme-Linked Immunosorbent Assay
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Biomarkers
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Chi-Square Distribution
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Linear Models
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Proportional Hazards Models
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Multivariate Analysis
Type of study:
Etiology study
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Observational study
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Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
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Aged
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Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2015
Document type:
Article