Insufficiency Fractures Related to Low-Dose Adefovir Dipivoxil Treatment for Chronic Hepatitis B
The Medical Journal of Malaysia
; : 38-41, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-630463
Responsible library:
WPRO
ABSTRACT
We present a case of a 53-year-old woman who developed multifocal insufficiency fractures associated with adefovir dipivoxil (ADV) induced osteomalacia, including recurring metatarsal insufficiency fractures and a subtrochanteric femoral insufficiency fracture requiring surgical fixation. She had received low-dose ADV treatment for 59 months for chronic hepatitis B viral infection at the time of presentation with subtrochanteric fracture. Imaging evidence of multifocal insufficiency fractures and metabolic disease on background of hypophosphatemia is attributed to hypophosphatemic osteomalacia from adefovir-induced renal proximal tubular dysfunction. Radiologists and clinicians should be aware of the possibility of insufficiency fractures in patients receiving ADV therapy to avoid delayed diagnosis and progression of high-risk proximal femoral fractures.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Osteomalacia
Language:
English
Journal:
The Medical Journal of Malaysia
Year:
2015
Document type:
Article