Association of coronary flow reserve by dipyridamole technetium-99m sestamibi single photon emission computed tomography with perfusion findings and risk factors for coronary artery disease
The Philippine Journal of Nuclear Medicine
; : 8-14, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-632930
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Blunting of coronary flow reserve (CFR) may precede overt ischemia. The study aimed to correlate CFR with perfusion findings and risk factors for coronary artery disease (CAD).METHODS:
Fifty-four consecutive patients underwent dipyridamole-rest technetium-99m sestamibi single photon emission computed tomography (SPECT) on two separate days. CFR was computed as the quotient of myocardial blood flow (MBF= global tissue perfusion divided by arterial input function) at stress and at rest.RESULTS:
CFR was significantly lower in patients with abnormal perfusion vs normals (p=0.005). Reduced CFR was noted in 83% of patients with normal SPECT. Lower CFR was seen in hypertensive patients with left ventricular hypertrophy (LVH) compared to those without LVH (p=0.029); likewise in DM vs no DM (p=0.121). Independent predictors of reduced CFR were age and extent of ischemia.CONCLUSION:
Abnormal perfusion is associated with reduced CFR. In those with normal perfusion, there is a high prevalence of reduced CFR, which may be attributed to the presence of risk factors for CAD and LVH.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Arteries
/
Coronary Artery Disease
/
Tomography, Emission-Computed, Single-Photon
/
Risk Factors
/
Technetium Tc 99m Sestamibi
/
Hypertrophy, Left Ventricular
/
Dipyridamole
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
The Philippine Journal of Nuclear Medicine
Year:
2015
Document type:
Article