Efficacy and safety of 24 hour rotigotine transdermal patch in the treatment of advanced Parkinson's disease: A meta-analysis

ABSTRACT

Advanced Parkinson's disease is often characterized by poor control of motor features with rapid oscillations between being on, being on with severe dyskinesias, and being off or frozen. As PD progresses, effective symptom control becomes more challenging, and a more complicated drug-regimen may be needed. OBJECTIVE: The objective was to perform a meta-analysis of randomized controlled trials of Rotigotine patch as treatment of advanced Parkinson's disease (PD). METHODS: A systemic literature search was conducted through August 2009. Both the efficacy and srlery endpoints were evaluated. RESULTS: The use of Rotigotine patch resulted in higher responder rates compared to placebo OR 0.37 (95% CI 0.35, 0.39). However, Rotigotine showed an adverse event profile similar to other dopamine agonists. CONCLUSION: The use of Rotigotine patch is an effective treatment option for the management of advanced PD but demands more study.