Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis
Yonsei Medical Journal
; : 879-884, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-63337
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations between the ALDH2 polymorphism and the risk of ALC. MATERIALS ANDMETHODS:
Relevant studies were retrieved by searching PubMed, Web of Science, CNKI, Wanfang and Veipu databases up to January 10, 2015. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using either the fixed- or random effects model.RESULTS:
A total of twelve case-control studies included 1003 cases and 2011 controls were included. Overall, the ALDH2 polymorphism was associated with a decreased risk of ALC (*1/*2 vs. *1/*1 OR=0.78, 95% CI 0.61-0.99). However, in stratification analysis by country, we failed to detect any association among Chinese, Korean or Japanese populations.CONCLUSION:
The pooled evidence suggests that ALDH2 polymorphism may be an important protective factor for ALC in East Asians.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Case-Control Studies
/
Odds Ratio
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Genetic Predisposition to Disease
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Asian People
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Protective Factors
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Aldehyde Dehydrogenase, Mitochondrial
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Liver Cirrhosis, Alcoholic
Type of study:
Etiology study
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Observational study
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Prognostic study
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Risk factors
/
Systematic review
Limits:
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
2016
Document type:
Article