Recent progress in the ubiquitination regulation of transforming growth factor-β/Smads signal transduction pathway in diabetic retinopathy / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology
; (12): 902-904, 2013.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-636229
Responsible library:
WPRO
ABSTRACT
Diabetic retinopathy (DR) is one of the common and serious diabetic complications,with a complex nosogenesis.Studies have shown that transforming growth factor-β (TGF-β) participates in the occurrence and development of DR,and Smads protein is able to mediate and activate TGF-β/Smads signal transduction pathway and further involves in the pathogenesis of DR.Smurf is one of the ubiquitin ligases in ubiquitin-proteasome pathway,and it is clarified to regulate TGF-β/Smads signal transduction pathway degradation.At present,the study on the relationship between TGF-β/Smads pathway and DR has made great progress.The role of ubiquitin-proteasome pathway regulating TGF-β/Smads signal transduction pathway in DR is reviewed in this article.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Experimental Ophthalmology
Year:
2013
Document type:
Article