Expression and Regulation of Cardiotrophin-1 in Ischemia1 Reinfusion Cardiac Muscle of Rats and Effect of Neuregwlin-1 / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics
; (24)1986.
Article
in Zh
| WPRIM
| ID: wpr-638643
Responsible library:
WPRO
ABSTRACT
Objective To observe the expression of cardiotrophin-1(CT-1) in ischemia-reinfusion cardiac muscle of rats and the effect of neuregulin-1(NRG-1).Methods The model of ischemia-reinfusion cardiac muscle of rats were prepared,35 rats were randomly divided into 4 groups:model group(n=8),NRG-1 pretreatment group(n=9),pseudo-surgery group(n=8) and normal control group(n=10).The CT-1 mRNA in the observed cardiac muscle of all groups was measured by RT-PCR and the relative amount of CT-1 mRNA were calculated,and for statistical treatment.Results The CT-1 mRNA of model group was(63.96?9.34),and it was higher than that of pseudo-surgery group(36.16?5.43)and normal control group(36.84?4.64).The significant differences were found in 3 groups(F=47.37 P
Full text:
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Database:
WPRIM
Language:
Zh
Journal:
Journal of Applied Clinical Pediatrics
Year:
1986
Document type:
Article