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Expressions of GATA-3 and Th2 Cytokines in Asthmatic Mice and Their Significances / 实用儿科临床杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-639098
Responsible library: WPRO
ABSTRACT
Objective To investigate the expressions and significances of GATA-3 and Th2 cytokines in asthmatic mice.Methods Sixteen BALB/c mice were randomly divided into control group and asthmatic group.The pathological changes in trachial and pulmonary tissue were observed with HE staining method.The GATA-3 mRNA expression in pulmonary tissue was messured with reverse transcription polymerase chain reaction(RT-PCR).And the IL-5,IL-13 proteins in pulmonary tissue were detected with enzyme linked immunosorbent assay(ELISA).Results HE staining showed infiltration of a great deal of inflammatory cells around the bronchial wall in asthmatic group,while there was no obvious infiltration in control group;Compared with control group,the expressions of GATA-3 mRNA and IL-5,IL-13 protein in pulmonary tissue increased significantly(Pa

Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Applied Clinical Pediatrics Year: 1994 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Applied Clinical Pediatrics Year: 1994 Document type: Article
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