Expressions of Transforming Growth Factor-?1 and Connective Tissue Growth Factor in Viral Myocarditis and Intervention Effect of Valsarta on Them / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics
; (24)2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-639995
Responsible library:
WPRO
ABSTRACT
Objective To explore the expressions of transforming growth factor(TGF)-?1 and connective tissue growth factor(CTGF) in viral myocarditis(VM) and the intervention effect of valsarta on them.Methods Fifty-four male Balb/c mice were randomly divided into 3 groupscontrol group,treatment group and model group.Model group and treatment group established VM model by intraperitoned injecting 0.1 ml CVB3.They were killed on days 7,14 and 28,respectively.Histological cross sections of heart were stained with hematoxylin-eosin and myocardial histopathplogic scores were counted under optical microscope.The expressions of typeⅠand Ⅲ myocardial collagen,TGF-?1 and CTGF were examined by immunohistochemical method and analyzed by using SPSS 11.5 software.Results Compared with control group,histopathplogic scores,the expressions of type Ⅰand Ⅲ myocardial collagen,TGF-?1 and CTGF increased markedly in model group (Pa
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Applied Clinical Pediatrics
Year:
2006
Document type:
Article