The role of MMP-9 and TIMP-3 in induction of choroidal neovascularization in a murine model / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
; (12): 1500-1503, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-641587
Responsible library:
WPRO
ABSTRACT
· AIM:
To examine the expression of MMP-9 and TIMP-3 mRNA during choroidal neovascularization (CNV) in a murine model and to investigate the role of them in the development of CNV. ·METHODS:
CNV was induced in C57BL/6J mice by intensive diode laser (810nm) photocoagulation (120mW, 75μm, 0. 1s) of the fundus whereafter eyes were enucleated at 1, 3days, 1, 2, and 4 weeks. The MMP-9 and TIMP-3 mRNA expression were analyzed using in situ hybridization and image analysis system. ·RESULTS:
Both expression of MMP-9 and TIMP-3 mRNA had dynamic changes. For MMP-9, the expression was 1, 2, 4 wk > 3d > 1d (P < 0.05), whereas TIMP-3 mRNA, 3d, 1, 2, 4 wk>1d (P<0.05). ·CONCLUSION:
The imbalance between the changes of MMP-9 and TIMP-3 may accelerate the degrading of extracelluar matrix, and then be involved in the pathogenesis of CNV.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Eye Science
Year:
2008
Document type:
Article