Effect of low intensity white light irradiation on the retinas of mice / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

AIM: To investigate the effect of low intensity white light irradiation on the retinas of mice. METHODS: Thirty C57BL/6J mice were randomly divided into two groups. The number of the mice in each group was 15. The mice in experimental group received dark adaptation from 500p. m. to 600p. m. , and then exposed to LED white light from 600p. m. to 700p. m. everyday for a month. At 1, 3, 7, 14 and 30d after the beginning, we examed the histology of mice retinas, calculated the thickness of outer nuclear layer ( ONL ) , inner nuclear layer ( INL ) and analyzed electrophysiology of mice. RESULTS:One month after experiment, compared to the control group, the latency of Rod-R a wave of the mice in experimental group significantly prolonged, the amplitude of Cone-R b wave of the mice in experimental group significantly decreased and the latency of b wave of the mice in experimental group significantly prolonged ( P CONCLUSION: 100lux low intensity white light could give rise to the impairment of the retinal functions in dark-adapted mice.