Effect of benflumetol on DNA content and pH value of the lysosome of Plasmodium berghei / 军事医学科学院院刊
Bulletin of The Academy of Military Medical Sciences
; (6): 31-33,38, 2001.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-642424
Responsible library:
WPRO
ABSTRACT
Objective:
To study the antimalarial mechanism of benflumetol (B).Methods:
Flow cytometry (FCM) was used to analyze the effects of B and chloroquine (CQ) on DNA content of Plasmodium berghei and pH value of the lysosome of malarial parasites.Results:
DNA content of the plasmodia not treated with any drugs was not changed in 24 hours,while benflumetol could decrease the DNA content the DNA content began to decrease 2 h after the drug administration and reached the minimum by 16 h, but somewhat increased at 24 h after administration. The pH in the lysosome increased 1 h and restored premedication level 4 h after benflumetol administration. Chloroquine had the same effects on DNA and lysosome pH of malarial parasites.Conclusions:
The antimalarial mechanism of benflumetol is directly related to its effect to inhibit the synthesis of DNA.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Bulletin of The Academy of Military Medical Sciences
Year:
2001
Document type:
Article