Screening of Interacting Proteins with PV.1 as Downstream Factors of BMP Signal / 대한해부학회지
Korean Journal of Anatomy
; : 203-210, 2007.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-644161
Responsible library:
WPRO
ABSTRACT
Homeodomain transcription factors functioning downstream of BMP ventral pathway have been reported to share similar domain of roles in mesoderm patterning along the dorsal-ventral axis. To elucidate the differential role of PV.1 in the aspect of relationship between dorsal and ventral region, we tried to screen PV.1- interacting proteins. Twenty-four PV.1-interacting proteins were identified by yeast two-hybrid screening. Xvent-2 and Xclaudin-6 among these, went under domain study. The C-terminus of PV.1, more specifically 197-241 region was found to interact with Xclaudin-6. Meanwhile Xvent-2 has mild affinity to overall C-terminal region of PV.1. At the same time it was found that Xvent-2 homodimerizes and also binds to Xclaudin-6.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Axis, Cervical Vertebra
/
Transcription Factors
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Xenopus laevis
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Yeasts
/
Mass Screening
/
Mesoderm
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Language:
Korean
Journal:
Korean Journal of Anatomy
Year:
2007
Document type:
Article