Spontaneous Bone Regeneration in Surgically Induced Bone Defects in Young Rabbits / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
; : 309-315, 2001.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-644452
Responsible library:
WPRO
ABSTRACT
PURPOSE:
To evaluate and compare the spontaneous regeneration repair process in femoral bone defects in 6-week-old rabbits and to compare the healing time periods between different rabbit groups. MATERIALS ANDMETHODS:
Bone defects were created at the femur mid-shaft and an external fixator was applied in 50 rabbits. The periosteum was resected in 10 rabbits (defect size 15%, 25%) and left untouched in the remaining rabbits. Forty rabbits were divided into four groups according to the percentage of bone defects (15%, 20%, 25%, 30%). Radiographs were taken weekly to evaluate the bone regeneration and union. The bone union time was measured between the osteotomy and the cortico-medullary differentiation by examining radiographs. The healing index was defined as the union time (week) per amount (cm) of bone defect. Eight rabbits, 2 from each groups with the bone defects, were investigated by histopathologic examination.RESULTS:
The mean union time was approximately 7.0 to 7.3 weeks. The healing index in groups that had a large percentage of bone defects was less than in groups that had a small percentage of bone defects. The periosteum-resected group did not show bone regeneration. Histopathologic examinations showed intramembranous and atypical endochondral ossifications along the periosteum and typical endochondral ossification at the center of the bone defects.CONCLUSION:
Spontaneous bone regeneration may be used in children to fill the bone defect instead of performing an internal bone transport. Spontaneous bone regeneration is useful in cases of mid-shaft bone defects or when the remaining bone fragments are large enough for an external fixation application.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Osteotomy
/
Periosteum
/
Regeneration
/
Bone Regeneration
/
External Fixators
/
Femur
Limits:
Animals
/
Child
/
Humans
Language:
Korean
Journal:
The Journal of the Korean Orthopaedic Association
Year:
2001
Document type:
Article