Distribution of Calcitonin Gene-Related Peptide Immunoreactive Nerve Fibers in Rat Cochlea and Brainstem Auditory Nuclei / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
; : 1239-1243, 1997.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-645622
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Calcitonin gene-related peptide(CGRP) is one of the neuronal elements of the inner ear. CGRP immunoreactive fibers are known to regulate auditory action potential and blood flow of cochlea.OBJECTIVES:
This study was designed to localize the CGRP immunoreactive fibers in the cochlear tissue and auditory brainstem of normal rat. MATERIAL ANDMETHODS:
Male Sprague-Dawley rats were perfused with 4% paraformaldehyde. Cochleae and brainstems were taken out and processed for surface preparations and frozen sections. Immunoperoxidase immunohistochemistry was carried out using anti-CGRP polyclonal antibody.RESULTS:
Numerous CGRP immunoreactive fibers were located in the inner spiral bundle, intraganglionic nerve fibers, base of inner hair cells and lateral superior olivary nuclei in brainstems.CONCLUSION:
CGRP is one of the neuropeptides in the olivocochlear effent system and may participate in the inhibitory effect on auditory action potential.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Neuropeptides
/
Brain Stem
/
Action Potentials
/
Calcitonin
/
Immunohistochemistry
/
Calcitonin Gene-Related Peptide
/
Rats, Sprague-Dawley
/
Cochlea
/
Frozen Sections
/
Hair
Limits:
Animals
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
1997
Document type:
Article