Prognostic Implications of MicroRNA-21 Overexpression in Invasive Ductal Carcinomas of the Breast / 한국유방암학회지
Journal of Breast Cancer
; : 269-275, 2011.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-64609
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Among more than 500 microRNAs, microRNA-21 (miR-21) is known to act as an oncogene. The aim of this study was to investigate the significance of miR-21 expression level in relation with clinicopathological factors and prognosis in breast cancer.METHODS:
MicroRNA was extracted from cancer and normal breast tissue of 109 breast cancer patients who underwent surgery from 2002 to 2004 using the Taqman(R) MicroRNA Assay. The correlation between miR-21 expression and clinicopathologic features was analyzed and the significance of miR-21 as a prognostic factor and its relationship with survival was determined.RESULTS:
MiR-21 expression was higher in cancer tissues than in normal tissues (p<0.0001). High miR-21 expression was associated with mastectomy, larger tumor size, higher stage, higher grade, estrogen receptor (ER) negative, human epidermal growth factor receptor 2 (HER2) positive, HER2 positive breast cancer subtype, high Ki-67 expression, and death. On multivariate analysis, prognostic factors for overall survival were ER and miR-21. High miR-21 expression was significantly related to lower overall survival (p=0.031).CONCLUSION:
This study supports the role of miR-21 as an oncogene and a biomarker for breast cancer with its high expression in cancer tissues and its relationship with other prognostic factors and survival.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Prognosis
/
Breast
/
Breast Neoplasms
/
Multivariate Analysis
/
Receptor, ErbB-2
/
MicroRNAs
/
Carcinoma, Ductal
/
Estrogens
/
ErbB Receptors
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Breast Cancer
Year:
2011
Document type:
Article