Alteration of laboratory findings after radiofrequency ablation of hepatocellular carcinoma: relationship to severity of the underlying liver disease and the ablation volume
Clinical and Molecular Hepatology
; : 71-79, 2015.
Article
in En
| WPRIM
| ID: wpr-64641
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
To investigate sequential changes in laboratory markers after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) and the relationship of these changes to the severity of the underlying liver disease.METHODS:
This retrospective analysis included 65 patients (44 males, 21 females) who underwent RFA of HCC. Hematologic and biochemical markers were assessed at the pre-RFA period and 1 day, 2-3 days, and 1-2 weeks after RFA. We classified the subjects into two groups Child-Pugh A (n=41) and Child-Pugh B (n=24). The ablative margin volume (AMV) of each patient was measured. We analyzed the changes in laboratory profiles from the baseline, and investigated whether these laboratory changes were correlated with the AMV and the Child-Pugh classification.RESULTS:
Most of the laboratory values peaked at 2-3 days after RFA. AMV was significantly correlated with changes in WBC count, hemoglobin level, and serum total bilirubin level (Pearson's correlation coefficient, 0.324-0.453; P<0.05). The alanine aminotransferase (ALT) level varied significantly over time (P=0.023).CONCLUSIONS:
Most of the measured laboratory markers changed from baseline, peaking at 2-3 days. The ALT level was the only parameter for which there was a significant difference after RFA between Child-Pugh A and B patients it increased significantly more in the Child-Pugh A patients.Key words
Full text:
1
Database:
WPRIM
Main subject:
Bilirubin
/
Severity of Illness Index
/
Biomarkers
/
Retrospective Studies
/
Follow-Up Studies
/
Catheter Ablation
/
Carcinoma, Hepatocellular
/
Alanine Transaminase
/
Liver Neoplasms
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
Clinical and Molecular Hepatology
Year:
2015
Document type:
Article