Coexistence of Tyrosine Hydroxylase and Nicotinamide Adenine Dinucleotide Phosphate-Diaphorase in Hypothalamic Neurons of the Rat / 대한해부학회지
Korean Journal of Anatomy
; : 119-126, 1998.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-648556
Responsible library:
WPRO
ABSTRACT
The presence and coexistence of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-diaphorase) with tyrosine hydroxylase (TH) was investigated by combining NADPH-diaphorase histochemistry with TH immunohistochemistry in hypothalamic nuclei of the rat. TH-immunoreactive and NADPH-diaphorase positive neurons were found in the medial preoptic area and medial preoptic nucleus, anterior hypothalamic area, dorsomedial hypothalamic nucleus, paraventricular nucleus, supraoptic nucleus and posterior hypothalamic area, respectively. TH and NADPH-diaphorase did not coexist in the anterior hypothalamic area, dorsomedial hypothalamic nucleus, medial preoptic area and posterior hypothalamic area. A considerable portion (30~50%) of the NADPH-diaphorase positive neurons in the supraoptic nucleus colocalized TH. In the medial preoptic area and paraventricular nucleus, some (5~15%) of TH-immunoreactive neurons also contained NADPH-diaphorase activity. NADPH-diaphorase is known to be an indicator of the enzyme nitric oxide synthase; these results therefore suggest that nitric oxide may play an important role in the regulation of the activity of the hypothalamic dopaminergic system of the rat.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Paraventricular Hypothalamic Nucleus
/
Preoptic Area
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Supraoptic Nucleus
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Tyrosine
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Tyrosine 3-Monooxygenase
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Immunohistochemistry
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Niacinamide
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Nitric Oxide Synthase
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Dorsomedial Hypothalamic Nucleus
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Anterior Hypothalamic Nucleus
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Anatomy
Year:
1998
Document type:
Article