Association of Epstein-Barr Virus and Head and Neck Cancer in an Endemic Area / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
; : 235-239, 2007.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-654176
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
A number of reports have suggested that Epstein-Barr virus (EBV) is associated with different forms of head and neck cancers (HNC) such as nasopharyngeal carcinoma, NK/T cell lymphoma and Burkitt's lymphoma. We evaluated the association of EBV with HNC as a causative factor in an endemic area of the virus. SUBJECTS ANDMETHOD:
Fresh specimens of HNC were obtained from 72 new patients between August 2003 and January 2005. In situ hybridization for EBER was performed with immunohistochemical staining of p53, Bcl-2 and LMP-1 and serologic tests on anti-viral capsid antigen(VCA) and anti-early antigen (EA)-D. The results of EBV positivity were analyzed according to tumor TNM stages, sites, pathology and smoking status. A correlation between EBV positivity and p53, Bcl-2, LMP-1 positive staining was investigated.RESULTS:
Nine (12%) of the total 72 patients showed EBV positivity of tumor, depending mainly on pathology and sites, but not tumor staging, age, sex or smoking status NPC (3), NK/T cell lymphoma (5), lymphoephithelial carcinoma of the parotid gland (1). All patients had sero-positivity of anti-VCA IgG but not anti-VCA IgM and anti-EA-D. There was a relationship between the presence of EBV, its oncoprotein (LMP-1) and oncogene (Bcl-2).CONCLUSION:
Overall, the incidence of EBV positivity of HNC in an endemic area is not significantly different from the prior reports about non-endemic area. The association between EBV and LMP-1 or Bcl-2 may be helpful for understanding the role of viral oncogenes in the HNC.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Parotid Gland
/
Pathology
/
Smoke
/
Immunoglobulin G
/
Immunoglobulin M
/
Serologic Tests
/
Smoking
/
Capsid
/
Incidence
Type of study:
Diagnostic study
/
Incidence study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2007
Document type:
Article