Intranasal Administration Model for Evaluating Protection Against Influenza Virus in Mice
Journal of Bacteriology and Virology
; : 44-50, 2015.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-65498
Responsible library:
WPRO
ABSTRACT
Antiviral activity against Influenza virus of 14 Lactobacillus species isolated from food was monitored. Lactobacillus species were isolated from traditional Korean fermented food. Each live Lactobacillus was administered into the nasal cavity of SPF 6-week-old BALB/c mice. After the Lactobacillus treatment, Influenza virus (A/NWS/33/H1N1) was inoculated to each mouse. Clinical signs and mortality was monitored for 21 days. Each Lactobacillus strain showed various level of antiviral activity against Influenza virus. As a result of this study, this mouse experiment model, including intranasal treatment of live Lactobacillus species, could be effective model in evaluating immunomodulatory response of probiotics against respiratory viruses.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Other Respiratory Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Orthomyxoviridae
/
Administration, Intranasal
/
Mortality
/
Probiotics
/
Models, Animal
/
Influenza, Human
/
Lactobacillus
/
Nasal Cavity
Type of study:
Prognostic study
Limits:
Animals
Language:
Korean
Journal:
Journal of Bacteriology and Virology
Year:
2015
Document type:
Article