Endothelial Dysfunction in Patients with Exaggerated Blood Pressure Response during Exercise Test
Korean Circulation Journal
; : 498-504, 2002.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-65743
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
The diagnostic and prognostic importance of exaggerated blood pressure response to exercise is controversial. Endothelial dysfunction has been demonstrated in patients with atherosclerosis and risk factors for coronary artery disease, but there is a lack of information in patients with exercise hypertension. Thus, we designed this study to evaluate the endothelial function in patients with exaggerated blood pressure response during exercise. SUBJECTS ANDMETHODS:
Exercise hypertension is defined as a systolic blood pressure >or= 210 mmHg in men, and >or=190 mmHg in female, during Treadmill tests. Using a high resolution ultrasound technique, the endothelial function of the brachial artery, in patients with exercise hypertension (n=25), and control subjects (n=25), were investigated.RESULTS:
Endothelial-dependent vasodilation were impaired in patients with exercise hypertension (7.77+/-5.14 vs. 2.81+/-2.29%, p<0.05). On univariate analysis, the extent of vasodilation was significantly correlated with age (r=0.43, p<0.05) and systolic blood pressure (r=0.39, p<0.05).CONCLUSION:
We conclude that patients with exercise hypertension have impaired endothelium-dependent vasodilation. Exercise hypertension is a finding, which may, by itself, raise concern when interpreted as an exercise test. This study also supports the concept that endothelial dysfunction may play a role in exercise hypertension.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Vasodilation
/
Blood Pressure
/
Coronary Artery Disease
/
Brachial Artery
/
Risk Factors
/
Ultrasonography
/
Endothelium
/
Atherosclerosis
/
Exercise Test
/
Hypertension
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2002
Document type:
Article