The application of double ovarian stimulation in the patients with low follicular output rate / 实用医学杂志

ABSTRACT

Objective To investigate the application value of double ovarian stimulations in the patients with low follicular output rate(FORT). Methods The data of 226 cases with low FORT at our hospital were ana-lyzed in this retrospective study. 67 patients received a subsequent luteal phase ovarian stimulation following regu-lar follicular phase stimulation(double stimulations group). The other 159 patients were performed fresh embryos transfer or whole embryos freezing(low FORT group),in which 60 patients who were not pregnant or had a pregnan-cy failure after fresh or freezing embryo transfer were served as control group and received conventional ovarian stimulation protocol in the next cycle. The clinical outcomes were compared among groups. Results The numbers of oocytes retrieved,metaphaseⅡoocytes,2PN fertilized oocytes,top-quality embryos in luteal phase stimulation were significantly higher than those in follicular phase stimulation(P < 0.05). Meanwhile,the parameters of IVF mentioned above along with cryopreserved embryos and the clinical pregnancy rate in double stimulations were sig-nificantly higher and the rate of abortion was significantly lower than low FORT group(P<0.05),which were simi-lar to control group(P > 0.05). Conclusions With the advantages of obtaining more available embryos in less time,the double stimulation could be served as an effective supplementary intervention for the patients with low FORT.