Tamibarotene alleviates cerebral ischemia reperfusion injury in rats / 基础医学与临床
Basic & Clinical Medicine
; (12): 1424-1428, 2017.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-659736
Responsible library:
WPRO
ABSTRACT
Objective To investigate the effect of tamibarotene(Am80)on cerebral ischemia reperfusion injury. Methods Rats were randomly divided into sham operation group(Sham),model group(I/R) and tamibarotene in-tervention group (Am80, intragastric administration of Am80 6 mg/kg). The middle cerebral artery occlusion (MCAO) was established by suture method. At 24 h after reperfusion,the brain was removed. And the neurological behavioral score was assessed by double blind method.The cerebral infarction volume was measured by TTC staining. The proteins of RARα,Bcl-2,Bax and mRNA were examined by Western blot and RT-qPCR,respectively. Results Am80 significantly improved the neurological deficits of MCAO rats and effectively reduced the infarct volume. And upregulated the level of RARα and Bcl-2, decreased the expression of Bax. Conclusions Am80 has a protective effect on cerebral ischemia-reperfusion in rats,and its effect may be related to anti-apoptosis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
/
Prognostic study
Language:
Chinese
Journal:
Basic & Clinical Medicine
Year:
2017
Document type:
Article