Progress in research on JAK/STAT3 signaling pathway regulating tumor and related biological functions / 基础医学与临床

ABSTRACT

JAK/STAT3 signal pathway is an important intracellular signal transduction pathway. It plays important roles in cell apoptosis and proliferation by affecting the activity of downstream effector molecules,and also induces embryonic development,liver regeneration,glycolysis and inflammation,epithelial-mesenchymal transition and an-giogenesis and a series of biogenesis process,closely related to the development of human cancer.