Dose Estimation Research Based on Uncertainty Parameter Model in Dose-re-sponse Clinical Studies / 中国卫生统计

ABSTRACT

Objective We introduces a method MCP-Mod ( Multiple Comparisons and Modeling) ,which can estimate the dose of dose-response studies. Based on the application conditions and analysis method of MCP-Mod,we explore the power to detect a dose-response relationship and the accuracy of model selection and target dose estimation using simulation data. Meth-ods Firstly,the research introduces the fundamental theory and application condition of the MCP-Mod method. Then,simulate data is set to evaluate the power to detect a dose-response relationship and the accuracy of model selection and target dose esti-mation. Results In the simulation,in the aspect of the power to detect a dose-response relationship6 groups of constant model have an approximately power 0f 0. 05 to detect the dose response relationship,which was similar toα=0. 05. For other parameter models,the larger the sample size,the higher power to detect a dose response relationship. In the aspect of accuracy of model selectionthe larger the sample size,the higher degree to identify various models. In the candidate models,exponential model and quadratic model have a high degree of identification,but linear model and logarithmic function have a low degree of identifica-tion. In terms of the accuracy of the dose estimationM