Progress of diagnosis and treatment of acute mixed-cell leukemia / 白血病·淋巴瘤

ABSTRACT

Acute mixed-cell leukemia (MPAL) is a rare high-risk leukemia that may originate from pluripotent hematopoietic stem cells.At present,the pathogenesis of MPAL is not clear,which mainly relys on immunophenotyping and molecular genetic diagnosis. Allogeneic hematopoietic stem cell transplantation may be the only way to cure the disease, depending on the immunophenotype and genetic characteristics of the leptin and/or myeloid induction chemotherapy. The prognosis of MPAL is worse than that of other acute leukemia, and understanding of these phenotypic genetic related clinical changes, biological significances and its pathogenesis will help to prevent and treat this disease effectively.