Progress in research of KISS1/KISS1R system and reproductive function / 中华内分泌代谢杂志

ABSTRACT

Kiss1 gene encodes Kisspeptins,an intercellular signal peptide whose corresponding receptor is Kiss1R. The initial study found that the Kiss1/Kiss1R system has the effect on inhibiting tumor metastasis. More and more evidence suggests that it can act on the hypothalamic-pituitary-gonadal(HPG) axis and is the key to puberty initiation and progression. It plays an important role in the neuroendocrine regulation of reproduction. In this paper, we reviewed the studies on Kiss1/Kiss1R system,its intracellular signal transduction pathway,role on HPG axis,and clinical application.