Peripheral Generation of CD4+ CD25+ Foxp3+ Regulatory T Cells
Immune Network
; : 1-9, 2007.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-66404
Responsible library:
WPRO
ABSTRACT
CD4+ CD25+ regulatory T cells (Tregs) expressing the lineage-specific marker Foxp3 represent an important regulatory T cell that is essential for maintaining peripheral tolerance. Although it was believed that Treg development is solely dependent on the thymus, accumulating evidence demonstrates that Tregs can also be induced in the periphery. Considering the various origins of peripherally developed CD4+ CD25+ Foxp3+ regulatory T cells, it seems likely that multiple factors are involved in the peripheral generation of Tregs.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Thymus Gland
/
T-Lymphocytes, Regulatory
/
Peripheral Tolerance
Language:
English
Journal:
Immune Network
Year:
2007
Document type:
Article