Studies on in vitro Transdermal Permeability of Nifedipine Nanoemulsion Containing Different Permeation Enhancers / 中国药师
China Pharmacist
; (12): 2156-2159, 2017.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-664122
Responsible library:
WPRO
ABSTRACT
Objective:
To study the in vitro transdermal permeability of nifedipine nanoemulsion ( NFNE) containing different per-meation enhancers to lay foundation for the development of transdermal nifedipine preparation.Methods:
Franz diffusion cells were used to study the transdermal enhancement of NFNE with different transdermal enhancers ( Azone, oleic acid, TMC20, TMC40, TMC60).Results:
The in vitro transdermal effect of NFNE was better than that of nifedipine (NF). The order of in vitro transdermal permeation enhancement was as follows azone > oleic acid > TMC60 > TMC40 > TMC20, while the water-soluble transdermal permeation enhancers had faster effect.Conclusion:
For NFNE, fat-soluble transdermal permeation enhancers have better effect.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2017
Document type:
Article