Effects of laparoscopic myomectomy on gastrointestinal function recovery and changes of serum IFN-γ and angiotensin Ⅱ in postoperative patients with uterine fibroids / 实用医学杂志

ABSTRACT

Objective To investigate the effect of laparoscopic myomectomy on recovery of gastrointestinal function and the changes of serum human interferon-γ(IFN-γ)and angiotensinⅡ(AngⅡ)levels in postoperative patients with uterine fibroids. Methods 79 patients were randomly divided into two groups according to different surgical procedures. The control group(39 patients)was treated with conventional open uterine myomectomy. The observation group(40 patients)was treated by laparoscopic myomectomy.The surgical situation,recovery of gastro-intestinal function,levels of serum IFN-γ,AngⅡ,ischemia modified albumin(IMA),myoglobin(MYO),and complications were compared between the two groups.Results Blood loss,pelvic drainage,discharge time,post-operative exhaust,bowel sound recovery,and postoperative defecation time were lowerin the observation group than in the control group.After one week,levels of serum IFN-γ,AngⅡ,IMA,and MYO were lower in the observation group than in the control group(P<0.05).The complication rate was lower in the observation groupthan in the con-trol group[5.00%(2/40)vs.23.08%(9/39),P<0.05].Conclusions Laparoscopic myomectomy can improve the levels of inflammatory factors and stress hormones in patients with uterine fibroids,promote the recovery of gastroin-testinal function,relieve oxidative damage,and decrease the incidence of complications.