Research progress of nucleic acid detection in cerebrospinal fluid / 中华检验医学杂志

ABSTRACT

The cerebrospinal fluid(CSF)is the most closely relatedbody fluidtocentral nervous system(CNS).Compared with other samples, CSF componentsare able to reflect the lesions of CNSmore directly.The detection of CSF pathogen nucleic acid is significantly better than the traditional detection method.Circulating tumor DNA(ctDNA)in CSF is very promising to be a diagnostic and monitoring marker for primary brain tumors and metastatic brain tumors.